WebMar 21, 2024 · PINK1 (PTEN Induced Kinase 1) is a Protein Coding gene. Diseases associated with PINK1 include Parkinson Disease 6, Autosomal Recessive Early-Onset and Parkinson Disease 2, Autosomal Recessive … WebMay 26, 2015 · The PTEN-induced putative kinase protein 1 (PINK1) and ubiquitin (UB) ligase PARKIN direct damaged mitochondria for mitophagy. PINK1 promotes PARKIN recruitment to the mitochondrial outer membrane (MOM) for ubiquitylation of MOM proteins with canonical and noncanonical UB chains.
The ubiquitin E3 ligase CHIP promotes proteasomal degradation …
WebMay 14, 2024 · The serine/threonine kinase phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) controls mitochondrial quality and plays a vital role in the pathogenesis of early-onset Parkinson's disease. However, whether PINK1 has functions in innate antiviral immunity is largely unknown. WebApr 8, 2024 · PTEN-induced putative kinase 1 (PINK1) mediates the canonical mitophagic pathway. However, the role of PINK1 in diseases where mitophagy has been purported to … cleaning a tile shower floor
PTEN-induced kinase PINK1 supports colorectal cancer …
WebSep 1, 2024 · PTEN induced putative kinase 1 (PINK1) is rapidly degraded in normal mitochondria but accumulates in damaged mitochondria, triggering autophagy to protect … WebMutations in the PTEN induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). So far, no substrates of PINK1 have been … WebFeb 23, 2024 · Is expressed in organism. Used to study Hirschsprung's disease; Parkinson's disease (multiple); and testicular cancer. Human ortholog (s) of this gene implicated in … downtown sheraton okc