WebNov 7, 2005 · The pNZ group was first described by Carpenter and Gish as an alternative to benzyloxycarbonyl (Z). 9 It has also been used for the protection of the ε-amino group of … WebPhthaloyl (Phth), tetrachlorophthaloyl (TCP), benzyloxycarbonyl (Cbz) and p- nitrobenzyloxycarbonyl (PNZ) were used for the protection of the amino functionality. The process of creating the dimers and the several synthetic steps towards its formation were compared in this work.
Use of p-nitrobenzyloxycarbonyl (pNZ) as a permanent protecting group …
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Utilization of the p-nitrobenzyloxycarbonyl (pNZ) amine protecting ...
WebNov 7, 2005 · This work demonstrates the utility of the p NZ group as a permanent protecting group in solid-phase peptide synthesis. p NZ can be used with Cl-Trt-resin to prepare peptides having acid sensitive residues, for which t Bu-type protection is not possible. The p NZ group is removed in solution or on-resin with SnCl 2 and a catalytic … WebThe protective group is temporarily attached to decrease reactivity so that the protected functional group does not react under synthetic conditions to which the molecule is … WebImportant representatives of the protecting group in this case are unsubstituted and substituted benzyl or benzyloxycarbonyl groups such as, for example, p-nitrobenzyl (PNB) … earl\u0027s whiskey bar winston salem nc