Cisplatin hyponatremia

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August undefined, 2024

WebJul 8, 2010 · Cisplatin based therapy for the treatment of solid organ tumors is commonly associated with several renal abnormalities including; *hypokalemia. * hypomagnesemia. … WebElectrolyte disorders with platinum-based chemotherapy: mechanisms, manifestations and management. Platinum chemotherapy, particularly cisplatin, is commonly associated …

Hyponatremia in patients with esophageal cancer treated with

WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and neck, bladder, ovarian, and testicular malignancies. 1,2 Approximately 20% of all cancer patients are … WebHyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) or gastrointestinal loss of sodium is sometimes seen during chemotherapy. However, … port charlotte splash pad

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WebKeywords: Cisplatin, Dehydration, Hyponatremia, Renal salt wasting, Siadh. Case Presentation: A 63-year-old male presents to the hospital with complaints of one-day history of weakness, dizziness. His outpatient blood work demonstrated a serum sodium level of 124 mEq/L, and a creatinine of 3.1 mg/dL. His medical history was significant for high ... WebAug 18, 2024 · Water losses from brain cells cause neurologic symptoms. Volume expansion and dilutional hyponatremia, without neurologic symptoms, can also be induced when isotonic mannitol is used as a flushing solution during transurethral resection of the prostate or bladder. Webhyponatremia was reported in 15% and 30.7% of 79 patients receiving brand and generic cisplatin respectively [16]. In our larger cisplatin treated cohort (n=298), all degree hyponatremia and moderate to severe hyponatremia was observed in 14.1% and 10% of patients respectively. In line with previous reports, hyponatremia was also irish pubs in jacksonville fl

Profound hyponatremia and dehydration: A case of cisplatin indu…

WebNov 1, 1997 · Cisplatin is one of the most widely used agents in cancer treatment. Cisplatin regimens can lead to a more or less pronounced hyponatremia in 4 to 10% of cases due to salt wasting with ... WebProfound hyponatremia and dehydration: A case of cisplatin induced renal salt wasting syndrome 1 INTRODUCTION. Cis-diamminedichloroplatinum (CDDP), commonly known … port charlotte social security officeWebCisplatin is similar to the bifunctional alkylating agents. It covalently binds to DNA and disrupts DNA function. 6. ... Hypophosphatemia and hyponatremia have occurred in some patients receiving cisplatin combination regimens. 2. These effects are due to renal tubular damage. Cisplatin greatly increases the urinary excretion of magnesium and port charlotte storm surge map

"WebNational Center for Biotechnology Information " - Cisplatin hyponatremia

Cisplatin hyponatremia

Hyponatremia in patients with esophageal cancer treated with

WebDec 3, 2014 · We retrospectively investigated the incidence of hyponatremia in patients receiving brand-name cisplatin (CDDP) and a generic counterpart thereof. Methods: We … Webmostly solid tumors had hyponatremia, and of these, 11% had moderate (sodium [Na] 120–129 mEq/L) to severe (Na , 120 mEq/L) hyponatremia (1). This is disproportionately higher than the hyponatremia prevalence rates of 15%–30% reported for general medicine admissions (2). In cancer patients with nonsolid tumors, rates of hyponatremia are less.

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WebMar 24, 2024 · Hyponatremia has been a recognized complication of platinum-based chemotherapy for decades. 7,8 There is limited data to quantify the overall incidence of … WebHyponatremia of grade 3 or above developed in 30.7% of the generic CDDP group compared to 15.1% of the brand-name CDDP group ( P =0.011). Multivariate analysis showed that the use of generic CDDP increased the incidence of hyponatremia (odds ratio =5.661, 95% confidence interval =1.403–22.839; P =0.015). Conclusion: Oncologists …

WebMar 15, 2024 · For patients who are unable to receive cisplatin due to medical frailty or comorbidities, options include a carboplatin-based regimen ( carboplatin plus gemcitabine, or carboplatin, gemcitabine, and paclitaxel) or a non-platinum-based combination (eg, paclitaxel plus gemcitabine) or even monotherapy (eg, gemcitabine). WebSep 1, 2024 · Cisplatin for injection has been administered at 20 mg/m 2 intravenously daily for 5 days per cycle. Other doses and combination regimens have been used. ... other electrolyte abnormalities (hypocalcemia, hyponatremia, hypokalemia, and hypophosphatemia), Syndrome of Inappropriate Antidiuretic Hormone Excretion …

WebFeb 16, 2024 · Hyponatremia, defined as a plasma sodium concentration lower than 135mmol/L, is the most common electrolyte disorder found in hospitalized patients.1 Its … WebApr 27, 2024 · Hyponatremia is a common adverse effect induced by cisplatin. Caution should be exercised with patients with a low sodium level before starting chemotherapy. Hyponatremia can be associated with other chemotherapy-related adverse effects, and it should therefore be treated correctly. Introduction

WebSep 15, 2024 · SIDE EFFECTS. Nephrotoxicity - Dose-related and cumulative renal insufficiency is the major dose-limiting toxicity of cis-platin.Renal toxicity has been noted in 28% to 36% of patients treated with a single dose of 50 mg/m 2.It is first noted during the second week after a dose and is manifested by elevations in BUN and creatinine, serum …

WebMar 23, 2024 · With a median follow-up of 12 months, 25 patients in the first-line group and 15 patients in the second-line group died of UTUC. For cisplatin-ineligible first-line patients, the median OS was 18.0 months (95% CI 4.1–31.9), the 1-year OS rate was 65.4%, and the median PFS was 5.0 months (95% CI 2.0–8.0; Figure 1A,B). irish pubs in ireland pics irish pubs in liverpool town centreWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … irish pubs in lake buena vista flWebWe report a case of a patient with hyponatremia and excessive urinary excretion of sodium after cisplatin-based chemotherapy. RSWS was diagnosed and the patient was treated … port charlotte storm surgeWebNov 21, 2024 · Cisplatin probably causes hyponatremia by causing SIADH and through its effect on the kidneys. ( 5 Trusted Source A Review of Drug-induced Hyponatremia Go to source) Painkillers: Opiates,... irish pubs in kansas city moWebApr 12, 2024 · AKI-related cisplatin may also be associated with tubulopathies, such as Fanconi-like syndrome, hypomagnesemia, salt-loosing syndrome and distal renal tubular acidosis . Tubular dysfunction is characterized by electrolyte disorders such as hyponatremia, hypokalemia and hypomagnesemia. irish pubs in lindenhurst nyWebDec 20, 2024 · Background: Hyponatremia is a common electrolyte abnormality in cancer patients who receive chemotherapy. Among anticancer agents, platinum-based agents are reported to cause chemotherapy-induced hyponatremia. However, the actual incidence and risk factors remain unknown. Results: The reports of 29 trials were analyzed. port charlotte storage peachland